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Clinical and Laboratory Standards Institute document H47-A2–One-Stage Prothrombin Time (PT) Test and Activated PartialThromboplastin Time (APTT) Test; Approved Guideline–Second Edition describes the principles and procedures necessary forthe routine performance of the PT and APTT by conventional techniques using citrated plasma. Each of the two tests measuresthe time for a fibrin clot to develop in test plasma after activation. The chemical reactions are complex and, characteristically,results are affected by preexamination (preanalytical) and examination (analytical) variables. The PT and APTT are importantscreening tests used in laboratory evaluation of patients suspected to have disorders of blood coagulation, including the presenceof circulating coagulation inhibitors. The PT measures the extrinsic or tissue factor pathway of the coagulation system and is usedto monitor oral anticoagulant therapy. The APTT measures the intrinsic coagulation pathway and is used in monitoring heparintherapy. The objective of this guideline is to improve test reproducibility through standardization of technique and ensure clinicalrelevance by setting test performance goals. The document also highlights the international effort for standardization of the PTthrough the use of the international normalized ratio (INR).
Product Details
- Edition:
- 2nd
- Published:
- 01/01/2008
- ISBN(s):
- 1562386727
- Number of Pages:
- 48
- File Size:
- 1 file , 400 KB
